Traditionally, oral formulations of vitamin D2 and D3 have long been regarded as equivalent in their clinical activity. However, studies indicate that ergocalciferol (vitamin D2) is much less potent and has a shorter duration of action than cholecalcifero
Armas and colleagues[11] administered single oral doses of 50,000 IU of the respective vitamin D preparations to 20 healthy male volunteers, and followed the time course of 25-hydroxyvitamin D levels over a period of 28 days. A pharmacokinetic analysis was also done. Both ergocalciferol and cholecalciferol produced similar initial increases in serum levels of 25-hydroxyvitamin D over the first 3 days, indicating equivalent absorption. However, levels continued to increase with cholecalciferol and peaked at day 14, whereas levels decreased rapidly with ergocalciferol and were no different from baseline at day 14. The investigators concluded that ergocalciferol potency is less than 30% of that of cholecalciferol and that it has a markedly shorter duration of action.
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Dr David Marcon
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Cincinnati, Ohio
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Vitamin D insufficiency (low serum levels of 25(OH)D) is predominant in numerous immune system ailments, for example, MS, TIDM, and SLE. Since the nutrient D status is exceptionally connected with the danger of autoimmunity, nutrient D has been involved in anticipation and insurance from immune system sicknesses.
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